BIOVIA COSMOtherm Description

BIOVIA COSMOtherm represents a sophisticated implementation of COSMO-RS that merges principles of quantum chemistry with thermodynamics to forecast the thermodynamic characteristics of liquid substances. It computes the chemical potential of molecules in both pure and mixed liquids at varying temperatures, thus allowing for the estimation of various properties including solubility, partition coefficients, vapor pressures, and phase diagrams. In contrast to other approaches, COSMOtherm utilizes thermodynamically consistent equations to derive properties as a function of concentration and temperature, which enhances its accuracy. This tool is capable of predicting the solubility of liquids, solids, and gases, as well as providing values for activity coefficients, two-phase partitioning such as LogP, phase behavior, vapor pressures, free energy of solvation, pKa, energy of transfer to liquid-liquid interfaces, micellar and membrane partitioning, and interfacial tension. Additionally, COSMOtherm is equipped with a user-friendly graphical interface alongside a command-line version, facilitating smooth integration into pre-existing workflows, making it a versatile choice for researchers in the field. Its comprehensive capabilities make it a valuable asset for those seeking to understand complex liquid systems more thoroughly.

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Company Details

Company:
Dassault Systèmes
Year Founded:
1981
Headquarters:
France
Website:
www.3ds.com/products/biovia/cosmo-rs/cosmotherm

Media

BIOVIA COSMOtherm Screenshot 1
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Product Details

Platforms
Windows
Types of Training
Training Docs
Live Training (Online)
Webinars
In Person
Training Videos
Customer Support
Business Hours
Live Rep (24/7)
Online Support

BIOVIA COSMOtherm Features and Options

Chemical Software

Certificates of Analysis
Chemical Process Simulation
Computer-Assisted Structure Elucidation (CASE)
ISO Management
Inventory Management
Particle Tracking
Reporting & Statistics
Samples Tracking
Traceability
Uncertainty Analysis

BIOVIA COSMOtherm User Reviews

Write a Review
  • Name: Ramakrishna K.
    Job Title: Simulation & modelling specialist
    Length of product use: 2+ Years
    Used How Often?: Daily
    Role: User
    Organization Size: 20,000 or More
    Features
    Design
    Ease
    Pricing
    Support
    Likelihood to Recommend to Others
    1 2 3 4 5 6 7 8 9 10

    Predictive Power Unleashed: A Deep Dive into BIOVIA COSMOtherm

    Date: Oct 28 2025

    Summary: BIOVIA COSMOtherm delivers a powerful and reliable platform for predicting thermodynamic properties of chemical systems without experimental data. Its COSMO-RS-based modeling is impressively accurate for solubility, partitioning, and mixture behavior, making it a go-to tool for formulation scientists and process engineers. The interface is intuitive, and its integration with other BIOVIA tools enhances workflow efficiency. While it demands a solid understanding of physical chemistry and comes with a premium price tag, the value it offers in accelerating R&D and supporting green chemistry initiatives is undeniable

    Positive: Accurate Property Prediction
    User-Friendly Interface
    Supports Sustainable Innovation
    Versatile Applications

    Negative: License Cost
    Steep Learning Curve
    Limited for Highly Complex Systems
    Computational Demands

    Read More...
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